Activated through the antibiotic rifampicin and many plant metabolites, like hyperforin, guggulipid, colupulone, and isoflavones. Reaction to specific ligands is species-certain. Activated by The natural way transpiring steroids, for instance pregnenolone and progesterone. Binds to a response factor inside the promoters in the CYP3A4 and ABCB1/MDR1